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Post-harvest treatment of wild-simulated ginseng under climate-smart environmental conditions

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PLOS One | https://doi.org/10.1371/journal.pone.0326237 June 18, 2025 6 / 6 Investigation: Taegon Kim. Methodology: Solhee Kim. Supervision: Jungyeon Kim, Kyo Suh. Validation: Solhee Kim. Visualization: Solhee Kim. Writing – original draft: Solhee Kim. Writing – review & editing: Jungyeon Kim, Kyo Suh. References 1. Nah SY. Ginseng; recent advances and trends. J Ginseng Res. 1997;21:1–12. 2. Kim Y-J, Jeon J-N, Jang M-G, Oh JY, Kwon W-S, Jung S-K, et al. Ginsenoside profiles and related gene expression during foliation in Panax gin- seng Meyer. J Ginseng Res. 2014;38(1):66–72. https://doi.org/10.1016/j.jgr.2013.11.001 PMID: 24558313 3. Kim K, Um Y, Eo H-J, Park HW, Jeon KS, Kim H-J. Study on the correlation between the ginsenoside contents and growth characteristics of wild-simulated ginseng with different year-roots (Panax ginseng C.A. Meyer). Korean J Plant Res. 2020;33:255–62. https://doi.org/10.7732/ kjpr.2020.33.4.255 4. Kim K, Huh JH, Um Y, Jeon KS, Kim HJ. The comparative of growth characteristics and ginsenoside contents in wild-simulated ginseng (Panax ginseng C.A. Meyer) on different years by soil properties of cultivation regions. Korean J Plant Res. 2020;33:651–8. https://doi.org/10.7732/ kjpr.2020.33.6.651 5. Ma R, Yang P, Jing C, Fu B, Teng X, Zhao D, et al. Comparison of the metabolomic and proteomic profiles associated with triterpene and phytos- terol accumulation between wild and cultivated ginseng. Plant Physiol Biochem. 2023;195:288–99. https://doi.org/10.1016/j.plaphy.2023.01.020 PMID: 36652850

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6. Hyun SH, Ahn H-Y, Kim H-J, Kim SW, So S-H, In G, et al. Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial. J Ginseng Res. 2021;45(1):191–8. https://doi.org/10.1016/j.jgr.2020.08.003 PMID: 33437171 7. Choi K. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin. 2008;29(9):1109–18. https://doi.org/10.1111/j.1745-7254.2008.00869.x PMID: 18718180 8. Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev. 2004;9(3):259–74. PMID: 15387718 9. Hong H, Baatar D, Hwang SG. Anticancer activities of ginsenosides, the main active components of Ginseng. Evid Based Complement Alternat Med. 2021;2021:8858006. https://doi.org/10.1155/2021/8858006 PMID: 33623532 10. Lin C-H, Lin Y-A, Chen S-L, Hsu M-C, Hsu C-C. American Ginseng attenuates eccentric exercise-induced muscle damage via the modulation of lipid peroxidation and inflammatory adaptation in males. Nutrients. 2021;14(1):78. https://doi.org/10.3390/nu14010078 PMID: 35010953 11. Park HJ, Jo S-M, Seo SH, Lee M, Lee Y, Kang I. Anti-inflammatory potential of cultured ginseng roots extract in lipopolysaccharide-stimulated mouse macrophages and adipocytes. Int J Environ Res Public Health. 2020;17(13):4716. https://doi.org/10.3390/ijerph17134716 PMID: 32630030 12. Saba E, Lee YY, Kim M, Kim S-H, Hong S-B, Rhee MH. A comparative study on immune-stimulatory and antioxidant activities of various types of

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ginseng extracts in murine and rodent models. J Ginseng Res. 2018;42(4):577–84. https://doi.org/10.1016/j.jgr.2018.07.004 PMID: 30344431 13. Korea Forest Service. 2023 Wild-Simulated Ginseng Statistical Report. 2024. 14. Sheban KC, Woodbury DJ, Duguid MC. Importance of environmental factors on plantings of wild-simulated American Ginseng. Agroforest Syst. 2021;96(1):147–60. https://doi.org/10.1007/s10457-021-00705-8 15. Aro EM, Virgin I, Andersson B. Photoinhibition of Photosystem II. Inactivation, protein damage and turnover. Biochim Biophys Acta. 1993;1143(2):113–34. https://doi.org/10.1016/0005-2728(93)90134-2 PMID: 8318516 16. Song J, Yang J, Jeong BR. Growth and photosynthetic responses to increased LED light intensity in Korean Ginseng (Panax ginseng C.A. Meyer) Sprouts. Agronomy. 2023;13(9):2375. https://doi.org/10.3390/agronomy13092375 17. Jeong B-G, Jung G-R, Kim MS, Moon H-G, Park S-J, Chun J. Ginsenoside contents and antioxidant activities of cultivated mountain ginseng (Panax ginseng C.A. Meyer) with different ages. Korean J Food Preserv. 2019;26(1):90–100. https://doi.org/10.11002/kjfp.2019.26.1.90